Hydrochloric Acid → 5-bromo-3-(2-ethyl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

Participants

Reaction Conditions

Reaction Steps

5-Bromo-3-[1-(2-ethyl-2H-pyrazol-3-yl)-2-methoxy-vinyl]-pyridin-2-ylamine (602 mg, 1.86 mmol), ethyl alcohol (30 ml), and concentration hydrochloric acid (30 ml) were combined and stirred at 100° C. for 18 hours. The reaction was quenched with sodium bicarbonate solution and the product was filtered off. The filtered product was dried under high vacuum to give 320 mg (59%) of 5-bromo-3-(2-ethyl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine. MS: m/z 291.3+293.3 (M+H+).

Provenance & Evidence