HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234684Generated: October 30, 2026
4-Pyridinemethanamine → 3-fluoro-5-iodo-N,N-dimethyl-2-[(pyridin-4-ylmethyl)-amino]-benzamide
https://huagongshe.com/reaction/2234684
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Pyridinemethanamine | HCID 77317 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,3-difluoro-5-iodo-N,N-dimethyl-benzamide | HCID 57975772 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-fluoro-5-iodo-N,N-dimethyl-2-[(pyridin-4-ylmethyl)-amino]-benzamide | HCID 57731552 | 99.9% |
Reaction Steps
2,3-Difluoro-5-iodo-N,N-dimethyl-benzamide (507, 1.63 mmol), 4-(aminomethyl)-pyridine (1.8 ml, 17.73 mmol), di-iso-propylethylamine (0.31 ml, 1.78 mmol), and dioxane (3 ml) were combined and stirred for 18 hours at 75° C. The reaction mixture was concentrated in vacuo to give approximately 650 mg of crude 3-fluoro-5-iodo-N,N-dimethyl-2-[(pyridin-4-ylmethyl)-amino]-benzamide, which was used directly in the next step. MS: m/z 400.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07709645B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-50c58df3dbba4c6f8abbd4b07732962e |
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| Source note | uspto-grants-2010_05 |
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