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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2234701Generated: October 29, 2026

Trifluoroacetic acid → HCID 57731620, compound

https://huagongshe.com/reaction/2234701

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 68694688HCID 68694688—
SolventDichloromethaneHCID 6344—
ProductHCID 57731620HCID 57731620—

Reaction Steps

To a solution of 2-tert-Butoxycarbonylamino-5-[3-(1H-indol-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid (308 mg, 0.66 mmol) in dichloromethane (9 mL) was added trifluoroacetic acid. The resulting solution was stirred for 2 hours at room temperature. The solution was concentrated to give the crude 2-amino-5-[3-(1H-indol-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid which was used in next step without further purification. MS: m/z 369 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07709645B2
Source datasetuspto-grants-2010_05
ORD IDord-e5f76d4646ff4eef93d174caf9f7f88e
Source noteuspto-grants-2010_05