Acetic Acid → HCID 178508958, compound

HRID 2234775Notes

Reaction equation

HRID 2234775 reaction equation
[NH2:1][C:2]1[NH:6][C:5]([CH:7]2[CH2:13][CH2:12][NH:11][C:10](=[O:14])[C:9]3[NH:15][C:16]([Cl:19])=[C:17]([Cl:18])[C:8]2=3)=[CH:4][N:3]=1.BrBr.CC(O)=[O:24]>>[NH2:1][C:2]1[NH:6][C:5](=[C:7]2[CH2:13][CH2:12][NH:11][C:10](=[O:14])[C:9]3[NH:15][C:16]([Cl:19])=[C:17]([Cl:18])[C:8]2=3)[C:4](=[O:24])[N:3]=1

Participants

4

Reactant 3

HCID 176Acetic Acid2×HCID 24408BromineHCID 597891934-(2-amino-3H-imidazol-4-yl)-2,3-dichloro-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one

Product 1

HCID 178508958HCID 178508958, compound

Procedure

To a solution of 4-(2-amino-3H-imidazol-4-yl)-2,3-dichloro-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one, prepared as in reference 2, (38 mg, 0.13 mmol) in AcOH (3 mL) is added NaOAc trihydrate (86 mg, 0.63 mmol). A solution of Br2 (40 mg, 0.25 mmol) in AcOH (1 mL) is added drop-wise, the mixture is stirred for an additional 30 minutes and concentrated. The residue is purified by HPLC (C18 column, eluted with CH3CN—H2O containing 0.05% TFA) to give 4-(2-amino-5-oxo-3,5-dihydro-imidazol-4-ylidene)-2,3-dichloro-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]azepin-8-one; 1H NMR (DMSO-d6) δ 3.18-3.26 (m, 2H), 3.26-3.32 (m, 2H), 8.09 (t, 1H, J=4.8 Hz), 8.68 (s, 1H), 9.37 (s, 2H), 11.11 (s, 1H), 13.46 (s, 1H); m/z [M++1] 314.0.

Workup

  1. concentrationconcentrated
  2. customThe residue is purified by HPLC (C18 column, eluted with CH3CN—H2O containing 0.05% TFA)

Sources & evidence

ORD record
ord-e4e28cda589d46c39e0762a684fbedca
Source dataset
uspto-grants-2010_05
Patent number
US07713958B2

Reaction notes

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