Water → HCID 87505693, compound

Participants

Reaction Steps

To a solution of compound 4.2 (800 mg, 1.01 mmol) in THF (20 mL) was added a 1.0 M solution of tetrabutylammonium fluoride in THF (1.5 mmol) at room temperature. The colorless solution was stirred for 4 hr at room temperature and then diluted by addition of 150 mL of CH2Cl2 and water (50 mL). The aqueous layers were extracted three times with CH2Cl2, and then dried over Na2SO4, filtered and evaporated. Purification by silica gel column chromatography using 1-2% MeOH in CH2Cl2 as eluent gave the desired compound 4.3 (460 mg, 67%) as a white solid.

Provenance & Evidence