Ammonium Hydroxide → HCID 21069730, compound

Participants

Reaction Steps

To a compound 6.2 (5 g, 6.7 mmol) in dioxane (100 mL) was added conc. NH4OH (100 mL). The mixture was heated in a stainless steel autoclave at 100° C. for 3 h, then cooled and evaporated in vacuo. The crude mixture was dissolved in 100 mL of CH2Cl2 and washed with water and brine, dried over MgSO4, filtered and concentrated to provide crude product. The crude product was then purified on a silica gel column with 5% MeOH in CH2Cl2 as eluent to give 4.32 g of 6.3 as white foam (yield 88%).

Provenance & Evidence