HCID 86612905, compound → HCID 178434909, compound

Participants

Reaction Steps

A mixture of tricyclic nucleoside 6.6 (20 mg, 0.06 mmol) and 10% Pd/C (12.8 mg, 0.2 eq.) in 20 mL of MeOH under H2 pressure (32 psi) was shaken for 7 hr at room temperature. The mixture was filtered through 0.45 μm filter. The combined filtrates were evaporated and purified on a silica gel column with 5% MeOH in CH2Cl2. 12 mg of pure compound 8.1 was obtained (yield 60%). 1H NMR (300 MHz, DMSO-d6): δ 10.65 (br s, 1H, NH), 8.37 (s, 1H, H-4), 7.48 (s, 1H, H-1), 6.12 (s, 1H, H-1′), 5.05 (m, 3H, 3×OH), 3.89-3.12 (m, 4H, H-3′, H-4′, 2×H-5′), 2.86-2.74 (m, 4H, 2×H-8, 2×H-9), 0.64 (s, 3H, CH3); LCMS: ES-MS 393.6 (+CH3COO).

Provenance & Evidence