Imidazole → HCID 131726595, compound

Participants

Reaction Steps

A mixture of 4-amino-2-(2-C-methyl-β-D-ribofuranosyl)-2,6-dihydro-7H-2,3,5,6-tetraazabenzo[cd]azulene-7-one (65 mg, 0.19 mmol) in DMF, tert-butyldimethylsilyl chloride (70 mg, 0.45 mmol) and imidazole (61 mg, 0.90 mmol) was stirred overnight at room temperature and then concentrated in vacuo. The oily residue was dissolved in CH2Cl2 (20 mL), washed with aq. HCl (0.1 N), sat. aq. NaHCO3, water, brine and dried (Na2SO4). The evaporated residue was purified on silica gel with hexanes/EtOAc (1/1)+0.5% Et3N and EtOAc+0.5% Et3N to yield the target compound 16.1 as colorless oil (38 mg, 44%).

Provenance & Evidence