Sodium borohydride → HCID 21921167, compound

HRID 2234808Notes

Reaction equation

HRID 2234808 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([NH:13][C:14](=[O:22])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[CH2:7]2)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:14]([NH:13][CH:8]2[CH2:7][C:6]3[C:10](=[CH:11][CH:12]=[C:4]([CH:1]([OH:3])[CH3:2])[CH:5]=3)[CH2:9]2)=[O:22])=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 21920974N-(5-Acetyl-indan-2-YL)-4-fluoro-benzamide

Product 1

HCID 21921167HCID 21921167, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

400 mg (1.35 mmol) N-(5-acetyl-indan-2-yl)-4-fluoro-benzamide were dissolved in 10 ml of methanol, then 100 mg (2.7 mmol) sodium borohydride were added. The mixture was worked up by dropping onto ice/HCl, the resulting solid was filtered off.

Workup

  1. filtrationthe resulting solid was filtered off

Sources & evidence

ORD record
ord-738cb29e6ef545d88ffaae2d06f50c70
Source dataset
uspto-grants-2010_05
Patent number
US07713963B2

Reaction notes

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