Boron tribromide → HCID 21920934, compound

HRID 2234809Notes

Reaction equation

HRID 2234809 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([NH:8][CH:9]2[CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:18]C)[CH:15]=3)[CH2:10]2)=[O:7])=[CH:4][CH:3]=1.B(Br)(Br)Br.ClCCl.CO>ClCCl>[F:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([NH:8][CH:9]2[CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:18])[CH:15]=3)[CH2:10]2)=[O:7])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 25134Boron tribromideHCID 21226129Dichloromethane methanolHCID 21921012HCID 21921012, compound

Product 1

HCID 21920934HCID 21920934, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.45 g (5.08 mmol) 4-fluoro-N-(5-methoxy-indan-2-yl)-benzamide were dissolved in 50 ml of dichloromethane, 13 ml (12.7 mmol) boron tribromide (1M in dichloromethane) were added, the whole was stirred for 30 min at RT. The resulting mixture was poured onto 200 ml of ice water, the organic phase was washed twice with water, dried, evaporated and the residue obtained was subjected to chromatography on silica with a mixture of dichloromethane/methanol 98:2.

Workup

  1. washthe organic phase was washed twice with water
  2. customdried
  3. customevaporated
  4. customthe residue obtained

Sources & evidence

ORD record
ord-3cae0ae0d1a44edcba1eb68f91a44394
Source dataset
uspto-grants-2010_05
Patent number
US07713963B2

Reaction notes

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