Benzenesulfonyl chloride → HCID 86587452, compound

HRID 2234810Notes

Reaction equation

HRID 2234810 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][CH:9]2[CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([OH:18])[CH:15]=3)[CH2:10]2)=[O:7])=[CH:4][CH:3]=1.[C:21]1([S:27](Cl)(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>N1C=CC=CC=1>[F:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([NH:8][CH:9]2[CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:18][S:27]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)(=[O:29])=[O:28])[CH:15]=3)[CH2:10]2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 21920934HCID 21920934, compound

Product 1

HCID 86587452HCID 86587452, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
70 °C

Procedure

95 mg (0.35 mmol) 4-fluoro-N-(5-hydroxy-indan-2-yl)-benzamide were dissolved in 2 ml of pyridine, 120 mg (0.72 mmol) of benzenesulfonic acid chloride were added, and the mixture was stirred for 5 h at 70° C.

Sources & evidence

ORD record
ord-7cbedbb0aecf4c9193a84784a26d7934
Source dataset
uspto-grants-2010_05
Patent number
US07713963B2

Reaction notes

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