Ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoate → Ethyl 2-(3-{3-[(2-heptyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazin-6-yl)-(4,4,4-trifluoro-butyl)-amino]-propoxy}-phenoxy)-2-methyl-propionate

HRID 2234867Notes

Reaction equation

HRID 2234867 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[N:12]([CH3:15])[C:11](=[O:16])[C:10]([N:17]([CH2:25][CH2:26][CH2:27][OH:28])[CH2:18][CH2:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[N:9]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].O[C:30]1[CH:31]=[C:32]([CH:42]=[CH:43][CH:44]=1)[O:33][C:34]([CH3:41])([CH3:40])[C:35]([O:37][CH2:38][CH3:39])=[O:36]>>[CH2:1]([N:8]1[C:13](=[O:14])[N:12]([CH3:15])[C:11](=[O:16])[C:10]([N:17]([CH2:18][CH2:19][CH2:20][C:21]([F:24])([F:23])[F:22])[CH2:25][CH2:26][CH2:27][O:28][C:30]2[CH:31]=[C:32]([CH:42]=[CH:43][CH:44]=2)[O:33][C:34]([CH3:40])([CH3:41])[C:35]([O:37][CH2:38][CH3:39])=[O:36])=[N:9]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 46835528Ethyl 2-(3-hydroxyphenoxy)-2-methylpropanoateHCID 59298834HCID 59298834, compound

Product 1

HCID 11856221Ethyl 2-(3-{3-[(2-heptyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazin-6-yl)-(4,4,4-trifluoro-butyl)-amino]-propoxy}-phenoxy)-2-methyl-propionate

Procedure

Compound 51 (oil) is prepared from triazine 9m and from intermediate 10b according to synthesis method 3 using Mitsunobu coupling conditions such as those described for example 33.

Workup

  1. customaccording to synthesis method 3 using Mitsunobu coupling conditions such as

Sources & evidence

ORD record
ord-b60620d3d17745d5ba19524ea7c69b52
Source dataset
uspto-grants-2010_05
Patent number
US07713971B2

Reaction notes

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