2-[3-(2-Amino-ethyl)-phenoxy]-2-methyl-propionic acid ethyl ester → Ethyl 2-{3-[2-(2-heptyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazin-6-ylamino)-ethyl]-phenoxy}-2-methyl-propionate
Reaction equation
Br[C:2]1[C:3](=[O:17])[N:4]([CH3:16])[C:5](=[O:15])[N:6]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[N:7]=1.[NH2:18][CH2:19][CH2:20][C:21]1[CH:22]=[C:23]([CH:33]=[CH:34][CH:35]=1)[O:24][C:25]([CH3:32])([CH3:31])[C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[CH2:8]([N:6]1[C:5](=[O:15])[N:4]([CH3:16])[C:3](=[O:17])[C:2]([NH:18][CH2:19][CH2:20][C:21]2[CH:22]=[C:23]([CH:33]=[CH:34][CH:35]=2)[O:24][C:25]([CH3:32])([CH3:31])[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[N:7]1)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]Participants
3
Reactant 2
Product 1
Procedure
Compound 57 (oil) is prepared from triazine 4b and from intermediate 13b according to synthesis method 1.
Workup
- customaccording to synthesis method 1
Sources & evidence
- ORD record
- ord-7b91c12922ac4460bf5756863cb27d7b
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07713971B2
Reaction notes
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