6-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione → Ethyl 2-(4-{2-[(2,4-dimethyl-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazin-6-yl)-heptyl-amino]-ethyl}-phenoxy)-2-methyl-propionate

HRID 2234871Notes

Reaction equation

HRID 2234871 reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[CH2:12]([NH:19][CH2:20][CH2:21][C:22]1[CH:36]=[CH:35][C:25]([O:26][C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:24][CH:23]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>>[CH3:8][N:6]1[C:5](=[O:9])[N:4]([CH3:10])[C:3](=[O:11])[C:2]([N:19]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:20][CH2:21][C:22]2[CH:36]=[CH:35][C:25]([O:26][C:27]([CH3:34])([CH3:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:24][CH:23]=2)=[N:7]1

Participants

3

Procedure

Compound 112 (oil) is prepared from triazine 1b and from intermediate 14a according to synthesis method 1.

Workup

  1. customaccording to synthesis method 1

Sources & evidence

ORD record
ord-906b934b08e446b0a6ba4ceff53b0eb7
Source dataset
uspto-grants-2010_05
Patent number
US07713971B2

Reaction notes

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