Ethyl Acetate → Tivantinib

Participants

Reaction Steps

A preparation of (±)-cis-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione (378 mg, 1.02 mmol) was heated to 50° C. in tert-butanol (10 ml) and potassium t-butoxide (11 mg, 98 μmol) for 16 hours. The mixture was poured into ethyl acetate (100 ml) and washed with water (100 ml). The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness to give (±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4(1H-indol-3-yl)pyrrolidine-2,5-dione as a tan powder (276 mg). 1H NMR (DMSO-d6) 400 MHz δ: 11.54(s, 1H), 11.03(s, 1H), 7.32-7.4(m, 4H), 7.17(d, 1H, J=7.2 Hz), 7.07(t, 1H, J=7.6 Hz), 6.96(t, 1H, J=7.6 Hz), 6.82-6.89(m, 2H), 4.5(dd, 2H, J=7.2 and 20 Hz), 4.07(t, 2H, J=5.2 Hz), 2.87(t, 2H, J=6 Hz), 2.08(m, 2H).

Provenance & Evidence