huagongshe.com
HRID2234892

反应详情

EQUATION

反应方程式

HRID 2234892 的结构方程式

REACTANTS

反应物

2
结构：NC(=O)Cc1ccc(F)cc1Cl
HCID2773716

2-(2-chloro-4-fluorophenyl)acetamide

C8H7ClFNO

结构：NC(=O)Cc1ccc(Cl)cc1Cl
HCID17190888

2,4-Dichlorobenzeneacetamide

C8H7Cl2NO

PRODUCTS

生成物

1
结构：O=C1NC(=O)[C@@H](c2cn3c4c(cccc24)CCC3)[C@@H]1c1ccc(Cl)cc1Cl
HCID86608199

未命名化合物

PROCEDURE

实验过程

(±)-Trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-(2,4-dichlorophenyl) pyrrolidine-2,5-dione was prepared according to Example 40 replacing 2-chloro-4-fluorophenylacetamide with 2,4-dichlorophenylacetamide. Yield 20.9 mg, 5.2%. 1H NMR (DMSO-d6) 400 MHz δ: 11.65 (s, 1H), 7.69 (s, 1H), 7.51 (d, 1H, J=8.0 Hz), 7.43 (d, 1H, J=8.0 Hz), 7.34 (s, 1H), 7.12 (m, 1H), 6.87 (m, 2H), 4.65 (d, 1H, J=7.6 Hz), 4.55 (d, 1H, J=7.6 Hz), 4.10 (t, 2H, J=6.0 Hz), 2.90 (t, 2H, J=6.0), 2.12 (t, 2H, J=6.0 Hz).