HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2,3-dihydro-7-methoxy-8-{3-[4-(4-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1-(4-Methoxyphenyl)-piperazine, dihydrochloride | HCID 2723700 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2,3-dihydro-7-methoxy-8-{3-[4-(4-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927682 | 45% |
Reaction Steps
Method A (60 h at 40° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(4-methoxyphenyl)piperazine dihydrochloride; yield 45%; fusion point 155°-156° C. (from ethanol). Fumarate: method E; yield 96%; fusion point 207°-210° C. (from acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-57010cf4a2a24ee98d82503afd07b327 |
| Source note | uspto-grants-1995_06 |