rel-(2R,6S)-2,6-dimethylpiperazine → HCID 58988142, compound

Participants

Reaction Steps

A solution of 4-bromo-N-(6-bromo-2-pyridinyl)-3-fluorobenzenesulfonamide (D1) (300 mg, 0.73 mmol) and cis-2,6-dimethylpiperazine (600 mg, 5.4 mmol) in 1-methyl-2-pyrrolidinone (5 ml) and water (0.5 ml) was microwaved at 200° C. for 2000 sec. The reaction mixture was diluted with ethyl acetate (20 ml) and washed with water (3×10 ml). The organic phase was dried and evaporated. Purification by column chromatography eluting with 5% methanol in dichloromethane afforded the title compound (D2), MS (ES+) m/e 443, 445 [M+H]+.

Provenance & Evidence