cis-1-(2-Chloro-4-pyridinyl)-3,5-dimethylpiperazine → 1,1-Dimethylethyl 5-[cis-3,5-dimethyl-1-piperazinyl]-2-(methyloxy)-3-pyridinecarboxylate

HRID 2234988Notes

Reaction equation

HRID 2234988 reaction equation
ClC1C=C([N:8]2[CH2:13][C@H:12]([CH3:14])[NH:11][C@H:10]([CH3:15])[CH2:9]2)C=CN=1.Br[C:17]1[CH:18]=[C:19]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C:20]([O:23][CH3:24])=[N:21][CH:22]=1>>[CH3:15][C@H:10]1[NH:11][C@@H:12]([CH3:14])[CH2:13][N:8]([C:17]2[CH:18]=[C:19]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C:20]([O:23][CH3:24])=[N:21][CH:22]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 58988144cis-1-(2-Chloro-4-pyridinyl)-3,5-dimethylpiperazineHCID 589881461,1-Dimethylethyl 5-bromo-2-(methyloxy)-3-pyridinecarboxylate

Product 1

HCID 589881481,1-Dimethylethyl 5-[cis-3,5-dimethyl-1-piperazinyl]-2-(methyloxy)-3-pyridinecarboxylate

Procedure

The title compound was prepared in a similar manner to cis-1-(2-chloro-4-pyridinyl)-3,5-dimethylpiperazine (D19) using 1,1-dimethylethyl 5-bromo-2-(methyloxy)-3-pyridinecarboxylate (D23) and cis-2,2-dimethylpiperazine as the starting materials.

Sources & evidence

ORD record
ord-083a563919aa40c4968e1c79a45822ac
Source dataset
uspto-grants-2010_05
Patent number
US07713978B2

Reaction notes

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