Hydrochloric Acid → HCID 68680072, compound

Participants

Reaction Steps

A solution of N-[5-[cis-3,5-dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinyl]-3-fluoro-4-(5-methyl-2-furanyl)benzenesulfonamide (D31) (60 mg, 0.1 mmol) in ethanol (5 ml) and 2M hydrochloric acid (0.5 ml) containing 10% palladium on carbon (10 mg) was stirred in a hydrogen atmosphere for 2 hours. The mixture was filtered through ‘celite’ and the solvent evaporated. Purification of the residue by flash chromatography eluting with 5% methanol in dichloromethane followed by treatment with 1.0M hydrogen chloride in diethyl ether gave the title compound (E13). MS (ES+) m/e 475 [M+H]+.

Provenance & Evidence