HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 8-{3-[4-(2-ethoxyphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 1-(2-Ethoxyphenyl)piperazine Hydrochloride | HCID 12862418 | — |
| Reactant | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 8-{3-[4-(2-ethoxyphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927670 | 72% |
Reaction Steps
Method B (40 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-ethoxyphenyl)piperazine hydrochloride; yield 72%; fusion point 169°-170° C. (from isopropanol). Fumarate: method E; yield 85%; fusion point 159°-161° C. (from acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-421451103625430ab5a0df477f7eea04 |
| Source note | uspto-grants-1995_06 |