Hydrochloric Acid → HCID 24969294, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-[5-[cis-3,5-dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinyl]-3-fluoro-4-(5-methyl-2-furanyl)benzenesulfonamide (D31) 60 mg, 0.1 mmol) in dioxan (2 ml) was treated with 4.0M hydrogen chloride in dioxan (1 ml) and water (0.5 ml). The mixture was heated at 70° C. for 4 hours. The solvent was evaporated and the residue dissolved in ethanol (5 ml) and 2M hydrochloric acid (2 ml). 10% Palladium on carbon (10 mg) was added and the mixture stirred in a hydrogen atmosphere for 4 hours. The mixture was filtered through ‘celite’ and the solvent was evaporated. Purification by MDAP gave the title compound (E15). MS (ES+) m/e 461 [M+H]+.

Provenance & Evidence