Acetic Acid → 1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Reaction Steps

Ethyl 8-bromo-1-[6-(tert-butylamino)-3,5-difluoropyridin-2-yl]-6,7-difluoro-4-oxo-1,4-dihydroquinolin-3-carboxylate (1.38 g) was added to a liquid mixture of 14% hydrochloric acid (3.5 mL) and acetic acid (3.5 mL), followed by stirring for five hours under reflux. Distilled water (5 mL) was added to the mixture, and the mixture was left to cool. The precipitate was collected through filtration, and washed sequentially with ethanol and diisopropyl ether, to thereby yield 1.10 g of the title compound as a colorless powder.

Provenance & Evidence