Hydrochloric Acid → HCID 66670165, compound

Participants

Reaction Steps

To a solution of the compound prepared in Example 1 in dichloromethane (150 mL) were added triethylamine (12.27 g) and methanesulfonyl chloride (6.65 g) on ice bath and the mixture was stirred at same temperature for 15 minutes. The reaction mixture was added by hydrochloric acid (1 mol/L), then the water layer was extracted with dichloromethane. The obtained extract was dried with anhydrous sodium sulfate and concentrated. The obtained residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1) to give the title compound (4.00 g) having the following physical data.

Provenance & Evidence