Trifluoroacetic acid → HCID 68581898, compound

Participants

Reaction Steps

1.9 g (75%, 5.5 mmol) methyl 4-(4-tert.-butoxycarbonylamino-2-oxo-pyrrolidin-1-yl)-2-methyl-benzoate are dissolved in 25 ml dichloromethane and combined with 4.4 ml TFA. The mixture is stirred for 18 hours at ambient temperature, then evaporated to dryness and the residue is purified by chromatography on silica gel (eluant: gradient dichloromethane/isopropanol/ammonia 90:10:0.2-dichloromethane/methanol/ammonia 50:50:0.4).

Provenance & Evidence