4-(Difluoromethoxy)benzenesulfonyl chloride → HCID 68699314, compound

Participants

Reaction Steps

2-Chloro-4-{[1-(4-difluoromethoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acid, m/z (ES+): 523.23 (M+H+.), was prepared in analogy to example 1, steps 1 to 5. Step 4 was performed using 4-difluoromethoxy-benzenesulfonyl chloride and yielded 2-chloro-4-{[1-(4-difluoromethoxy-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acid methyl ester, which was hydrolyzed in step 5.

Provenance & Evidence