3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 68697386, compound

Participants

Reaction Steps

2-Fluoro-4-{[1-(3-trifluoromethyl-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}benzoic acid, m/z (ES+): 509.2 (M+H+.), was prepared in analogy to example 9, steps 1 to 5. Step 4 was performed using 3-trifluoromethyl-benzenesulfonyl chloride and yielded 2-fluoro-4-{[1-(3-trifluoromethyl-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carbonyl]-amino}-benzoic acid ethyl ester, which was hydrolyzed in step 5.

Provenance & Evidence