Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2,3-dihydro-8-{3-[4-(2-hydroxyphenyl)-1-piperazinyl]propoxy}-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | o-(1-Piperazinyl)phenol dihydrobromide | HCID 3017100 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2,3-dihydro-8-{3-[4-(2-hydroxyphenyl)-1-piperazinyl]propoxy}-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927699 | 54% |
반응 단계
Method A (40 h at 50° C.; 4 equivalents of potassium carbonate); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-hydroxyphenyl)piperazine dihydrobromide; yield 54%; fusion point 136°-139° C. (from chloroform and ethanol). Fumarate: method E; yield 84%; fusion point 196°-199° C. (from acetone).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-ee7f6800e5e340bb926d02bf5856a982 |
| 출처 메모 | uspto-grants-1995_06 |