4-(Difluoromethoxy)benzenesulfonyl chloride → HCID 68698522, compound

Participants

Reaction Steps

2-Chloro-4-{[1-(4-difluoromethoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-benzoic acid, m/z (ES+): 537.24 (M+H+.), was prepared in analogy to example 40, steps 1 to 5. Step 4 was performed using 4-difluoromethoxy-benzenesulfonyl chloride, yielding 2-chloro-4-{[1-(4-difluoromethoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-benzoic acid methyl ester, which was hydrolyzed in step 5.

Provenance & Evidence