HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Difluoromethoxy)benzenesulfonyl chloride → HCID 68699741, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Difluoromethoxy)benzenesulfonyl chloride | HCID 2778223 | — |
| Reactant | 4-{[1-(4-Difluoromethoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-2-fluoro-benzoic acid | HCID 16050716 | — |
| Product | HCID 68699741 | HCID 68699741 | — |
Reaction Steps
4-{[1-(4-Difluoromethoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-2-fluoro-benzoic acid, m/z (ES+): 521.17 (M+H+.), was prepared in analogy to example 48, steps 1 to 5. Step 4 was performed using 4-difluoromethoxy-benzenesulfonyl chloride, yielding 4-{[1-(4-difluoromethoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-2-fluoro-benzoic acid ethyl ester, which was hydrolyzed in step 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713996B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-26aa5f2c44324874b27214259714c00b |
| Source note | uspto-grants-2010_05 |