Benzocaine → HCID 68699650, compound

HRID 2235171Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:25][CH3:26])=[C:6]([S:8]([N:11]2[CH2:17][CH2:16][CH2:15][CH2:14][C:13]3[CH:18]=[CH:19][C:20]([C:22](O)=[O:23])=[CH:21][C:12]2=3)(=[O:10])=[O:9])[CH:7]=1.[NH2:27][C:28]1[CH:38]=[CH:37][C:31]([C:32]([O:34][CH2:35][CH3:36])=[O:33])=[CH:30][CH:29]=1>>[CH2:35]([O:34][C:32](=[O:33])[C:31]1[CH:30]=[CH:29][C:28]([NH:27][C:22]([C:20]2[CH:19]=[CH:18][C:13]3[CH2:14][CH2:15][CH2:16][CH2:17][N:11]([S:8]([C:6]4[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=4[O:25][CH3:26])(=[O:9])=[O:10])[C:12]=3[CH:21]=2)=[O:23])=[CH:38][CH:37]=1)[CH3:36]

Participants

Reactant 2

HCID 2337Benzocaine

HCID 68433680HCID 68433680, compound

Product 1

HCID 68699650HCID 68699650, compound

Procedure

1-(5-Chloro-2-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-8-carboxylic acid was reacted with ethyl 4-aminobenzoate in analogy to example 62, step 4, yielding 4-{[1-(5-chloro-2-methoxy-benzenesulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-8-carbonyl]-amino}-benzoic acid ethyl ester. Light brown solid, MS (ISP) 543.2 (M+H).

Sources & evidence

ORD record: ord-0c291e1f32e3457b8152d22486d8c813
Source dataset: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07713996B2

Reaction notes

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