HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Cyclohexyl-2-pyrrolidone → 3-(4-Bromo-2-chlorobenzyl)-1-cyclohexylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Cyclohexyl-2-pyrrolidone | HCID 81278 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 4-Bromo-1-(bromomethyl)-2-chlorobenzene | HCID 21914486 | — |
| Product | 3-(4-Bromo-2-chlorobenzyl)-1-cyclohexylpyrrolidin-2-one | HCID 11682206 | 66.2% |
Reaction Steps
Using the procedure to synthesize Example 1 and using reagents N-cyclohexylpyrrolidinone (15 g, 89.7 mmol), LDA (2.0 M, 53.8 mL, 107.6 mmol) and 4-bromo-1-bromomethyl-2-chloro-benzene (preparation 5) (30.6 mg, 107.6 mmol) affords 22 g (66%) of 3-(4-bromo-2-chloro-benzyl)-1-cyclohexyl-pyrrolidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713979B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-89692a0728284591aa657e1e13934bb5 |
| Source note | uspto-grants-2010_05 |