4-Oxo-4-(2-oxo-oxazolidin-3-yl)-butyraldehyde → HCID 178516219, compound

HRID 2235204Notes

Reaction equation

HRID 2235204 reaction equation
[O:1]=[C:2](N1CCOC1=O)[CH2:3][CH2:4][CH:5]=O.[NH2:13][C@@H:14]1[CH2:19][CH2:18][C@H:17]([CH2:20][OH:21])[CH2:16][CH2:15]1>>[OH:21][CH2:20][C@@H:17]1[CH2:18][CH2:19][C@H:14]([N:13]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:1])[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 106072654-Oxo-4-(2-oxo-oxazolidin-3-yl)-butyraldehydeHCID 178511559HCID 178511559, compound

Product 1

HCID 178516219HCID 178516219, compound

Procedure

Using the method of Example 167, 4-oxo-4-(2-oxo-oxazolidin-3-yl)-butyraldehyde (Dominique Urban, Troels Skrydstrup, and Jean-Marie Beau, J. Org. Chem., 1998, 63(8), 2507-2516) (4.2 g, 24.54 mmol) and (cis-4-amino-cyclohexyl)-methanol (Thomas P. Johnston, etc. J. Med. Chem., 1977, 20(2), 279-290) (3.17 g, 24.54 mmol) yield 4.87 g (100%) of the title compound as a colorless oil.

Sources & evidence

ORD record
ord-c4bf847ab62042febb922b806a0b04be
Source dataset
uspto-grants-2010_05
Patent number
US07713979B2

Reaction notes

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