Hydrochloric Acid → HCID 68470799, compound

Participants

Reaction Steps

Dissolve 7-methyl-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester (R. R. Crenshaw, etc., J. Med. Chem., 1973, 16(7), 813-823) (14.09 g, 61.7 mmol) in MeOH (300 mL) and add 2M KOH (60 mL, 120 mmol, 2M in H2O). Stir the reaction for overnight at room temperature, then add 1N HCl until pH=3. Remove MeOH under reduced pressure and add water (200 mL). Extract the aqueous layer with ethyl acetate (3×400 mL). Combine the organic layers and dry with Na2SO4, filter and concentrate to give 11.74 g (95%) of the crude title compound as a white solid

Provenance & Evidence