反应详情

温度

0 °C

Dissolve 2,4-dichloro-phenol (30 g, 184 mmol) and cool to 0° C. Add imidazole (28 g, 405 mmol) followed by t-butyldimethylsilyl chloride (31 g, 202 mmol). Warm reaction mixture to room temperature, and stir for 20 minutes. Pour reaction mixture into water and extract with ether. Separate layers and wash organics with water, 2× brine, dry over sodium sulfate, filter and concentrate to yield 48.4 g (95%) of tert-butyl-(2,4-dichloro-phenoxy)-dimethyl-silane.

1. temperatureWarm
2. customreaction mixture to room temperature
3. additionPour
4. extractionextract with ether
5. washSeparate layers and wash organics with water, 2× brine
6. dry with materialdry over sodium sulfate
7. filtrationfilter
8. concentrationconcentrate