反应详情

Dissolve 2,6-dichloro-3-methoxy-benzaldehyde (10 g, 48.8 mmol) in ethanol (330 ml) add sodiumborohydride (1.8 g, 48.8 mmol) and stir at room temperature over night. Partition reaction mixture between water and ethyl acetate separate layers wash organic with brine, dry over sodium sulfate, filter and concentrate to yield 9.43 g (93%) of (2,6-Dichloro-3-methoxy-phenyl)-methanol.

1. customPartition
2. customreaction mixture between water and ethyl acetate
3. customseparate layers
4. washwash organic with brine
5. dry with materialdry over sodium sulfate
6. filtrationfilter
7. concentrationconcentrate