HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-((Tert-butoxy)carbonyl)phenyl)boronic acid → 3'-Chloro-4'-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-((Tert-butoxy)carbonyl)phenyl)boronic acid | HCID 2773301 | — |
| Reactant | 3-(4-Bromo-2-chlorobenzyl)-1-cyclohexylpyrrolidin-2-one | HCID 11682206 | — |
| Product | 3'-Chloro-4'-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid tert-butyl ester | HCID 59299321 | 78.3% |
Reaction Steps
Using the procedure to synthesize Example 81 and using reagents 3-(4-bromo-2-chloro-benzyl)-1-cyclohexyl-pyrrolidin-2-one (500 mg, 1.35 mmol) and 4-(tert-butoxycarbonyl)phenylboronic acid (900 mg, 4.0 mmol) affords 495 mg (78%) of the title compound: Mass spectrum (apci) m/z=468.2 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713979B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-992fb4d318a84a3c9fbd45b98f98a556 |
| Source note | uspto-grants-2010_05 |