Boron tribromide → HCID 11543630, compound

Participants

Reaction Steps

Add boron tribromide (0.21 mL, 2.2 mmol) to a solution of 1-cyclohexyl-3-(2-methoxy-benzyl)-pyrrolidin-2-one (210 mg, 0.73 mmol) in dichloromethane (5 mL). Stir 20 minutes. Pour mixture onto a mixture of ice and saturated sodium bicarbonate. Stir 5 minutes. Wash the organic layer with water, brine, dry, concentrate, and purify the residue on a Biotage cartridge, eluting with 4:1 hexanes:ethyl acetate to afford the title compound (115 mg): MS (APCI-pos mode) m/z (rel intensity) 274 (100).

Provenance & Evidence