p-Toluenesulfonic acid → HCID 11624255, compound

Participants

Reaction Steps

Dissolve 3-(2,4-dichloro-benzyl)-1-(4-hydroxy-cyclohexyl)-pyrrolidin-2-one (14.56 g, 37.90 mmol) in acetone (400 mL) with stirring at room temperature. Add p-toluene sulfonic acid (6.53 g, 37.90 mmol) and stir the reaction at room temperature for 48 hours. Then add water and extract the aqueous layer with ethyl acetate (3×400 mL). Combine the organic layers and dry with Na2SO4. Filter and concentrate to give 12.95 g (100%) of the crude title compound as a white solid: Mass spectrum (ion spray): m/z=340.1, 342.0 (M+1).

Provenance & Evidence