Potassium Carbonate → HCID 178515595, compound

Participants

Reaction Steps

Dissolve cis-4-nitro-benzoic acid 4-[3-(2,4-dichloro-benzyl)-2-oxo-pyrrolidin-1-yl]-cyclohexyl ester (Example 16) (3.58 g, 7.29 mmol) in MeOH (200 mL). Add 2M K2CO3 (50 nL) and stir the reaction mixture overnight. Add water (200 mL) and extract the aqueous layer with ethyl acetate (3×300 mL). Combine the organic layers and dry with Na2SO4, filter, concentrate and purify by flash column chromatography (silica gel, 50-100% of EtOAc-Hexane) to give 1.54 g (62%) of the title compound as a white solid. Mass spectrum (ion spray): m/z=342.0, 344.0 (M+1).

Provenance & Evidence