Tetrabutylammonium Fluoride → HCID 178515594, compound

Participants

Reaction Steps

Dissolve 1-[cis-4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-3-(2,4-dichloro-benzyl)-pyrrolidin-2-one (Preparation 37) (0.12 g, 0.25 mmol) in THF (50 mL) and add TBAF (0.50 mL, 1.0 M in THF) at room temperature under nitrogen. Stir the solution overnight. Then add water (50 mL) and extract the aqueous layer with dichloromethane (3×100 mL). Combine the organic layers and dry with Na2SO4, filter, concentrate and purify by flash column chromatography (silica gel, 50-80% EtOAc-Hexane) to give 0.085 g (95%) of the title compound as a white solid: Mass spectrum (ion spray): m/z=356.2, 358.2 (M+1).

Provenance & Evidence