HCID 59299525, compound → HCID 178515522, compound

Participants

Reaction Steps

Place 3-(2-chloro-4-(2-methoxypyridin-3-yl)benzyl)-1-cyclohexylpyrrolidin-2-one (Example 105) (120 mg, 0.3 mmol) in dichloromethane (10 mL) and cool to 0° C. Add borontribromide (226 mg, 0.9 mmol) and stir of 16 hours. Add water and extract with dichloromethane. Dry over sodium sulfate, filter, and concentrate. Purify by silica gel (10% methanol in dichloromethane) to yield 65 mg (56%) of the title compound: Mass spectrum (apci) m/z=385.2 (M+H).

Provenance & Evidence