Tetrahydrofuran → HCID 59299517, compound

Participants

Reaction Steps

Dissolve 3-chloro-4-((1-cyclohexyl-2-oxopyrrolidin-3-yl)methyl)benzonitrile (0.20 g, 0.63 mmol) in THF (20 mL) under N2 and add phenylmagnesium bromide (0.63 mL, 0.63 mmol, 1.0 M in THF). Stir the reaction mixture for 24 hours until LC-MS shows the starting material has gone. Add saturated NH4Cl (20 mL) and extract the aqueous with EtOAc (3×50 mL). Combine the organic layers and dry with Na2SO4, filter, concentrate and purify by flash column chromatography (silica gel, 20-50% of EtOAc-Hexane) to give 0.023 g (9%) of the title compound as white solid: MS (APCI-pos mode) m/z (rel intensity) 396.3 (100), 398.2 (30).

Provenance & Evidence