N-bromobutanimide → HCID 11539010, compound

Participants

Reaction Steps

Add NBS (7.82 g, 43.9 mmol) to a solution of 3-(3-amino-2,6-dichlorobenzyl)-1-cyclohexyl-pyrrolidin-2-one (Example 50) (15.0 g, 43.9 mmol) in CCl4 (500 mL). Stir at room temp overnight. Filter the suspension. Concentrate the filtrate. Form a suspension in CH2Cl2 and filter. Dissolve the solid in CH2Cl2 and wash several times with water. Dry, filter and concentrate. Concentrate the filtrate. Purify the combined residue by a plug of silica gel eluting with a mixture of EtOAc and hexanes (20:80) to give the title compound (17.6 g, 96%): Mass spectrum (apci) m/z=421.1 (M+H).

Provenance & Evidence