HCID 178421967, compound → HCID 178421966, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 3-(2,4-dichloro-benzyl)-1-(cis-4-t-butyldimethylsilyloxy-cyclohexyl)-3-methyl-pyrrolidin-2-one and 3-(2,4-dichloro-3-methyl-benzyl)-1-(cis-4-t-butyldimethylsilyloxy-cyclohexyl)-3-methyl-pyrrolidin-2-one (0.42 g, 0.89 mmol) in ethanol-2N HCl (1:1, 9 mL) and stir at 70° C. 2 h. Cool the mixture and partition between dichloromethane and saturated aqueous sodium bicarbonate and brine, dry the organic layer over sodium sulfate and evaporate. Purify the residue by column chromatography on silica gel (eluting 0% to 100% ethyl acetate in hexane) to give the desired product (97 mg, 31%). MS(ES+) m/z=356.

Provenance & Evidence