Bicarbonate Ion → HCID 59299500, compound

Participants

Reaction Steps

Charge a flask with 3-(4-amino-2,6-dichlorobenzyl)-1-cyclohexylpyrrolidin-2-one (250 mg, 0.73 mmol) and dissolve in methylene chloride (3 mL). Add triethylamine (0.16 ml) followed by sulfonyl chloride (0.11 ml, 1.5 mmol) and stir at room temperature for 1 hour. Pour into saturated aqueous bicarbonate and extract with methylene chloride. Dry over soium sulfate, filter and concentrate in vacuo. Purify residue over silica gel (30% ethyl acetate in hexanes) to afford 184 mg (60%) of the title compound. Mass spectrum (apci) m/z=419.1 (M+H).

Provenance & Evidence