Nitric Acid → HCID 87395363, compound

Participants

Reaction Steps

To a solution of 2,2,2-trifluoro-N-(2′-oxo-1′-pentyl-spiro[cyclopropane-1,3′-indole]-5′-yl)-acetamide (2.4 g) in acetic acid (20 ml) is added nitric acid (fuming, 0.9 ml) at 15° C. over a period of 3 min. The mixture is stirred at this temperature for 1 h and then diluted with water. The aqueous layer is extracted with Et2O (2×50 ml) The combined organic layer is washed with water, saturated K2CO3 solution and brine, dried over MgSO4 and evaporated. The compound (2.6 g) is obtained as brownish oil.

Provenance & Evidence