Nitric Acid → HCID 67426429, compound

Participants

Reaction Steps

To a solution of (rac)-3-isopropyl-1-methyl-1,3-dihydro-indol-2-one (4.5 g) (J. Chem. Soc. Chem. Commun. 1986, 115-116) in concentrated sulfuric acid (7 ml) is added drop-wise a mixture of nitric acid (65%, 1.7 ml) and concentrated sulfuric acid (2.8 ml) at 0° C. over a period of 30 min. The reaction mixture is stirred at this temperature for 30 min and then poured into ice-water. The precipitate is collected by filtration and washed with water to give the title compound (3.4 g).

Provenance & Evidence