反应详情

2-Methyl-5-hydroxymethylpyridine (0.1 mole) is stirred in pyridine (50 ml.) with acetic anhydride (0.15 mole) at room temperature overnight. The mixture is concentrated to dryness, and the residue is dissolved in 70 ml. of water and extracted with 3×25 ml. of chloroform. After drying over magnesium sulfate, the chloroform is concentrated to dryness to give 2-methyl-5-acetoxymethylpyridine.

1. concentrationThe mixture is concentrated to dryness
2. dissolutionthe residue is dissolved in 70 ml
3. extractionof water and extracted with 3×25 ml
4. dry with materialAfter drying over magnesium sulfate
5. concentrationthe chloroform is concentrated to dryness