Nitric Acid → HCID 23092667, compound

HRID 2235360Notes

Reaction equation

HRID 2235360 reaction equation
[CH2:1]([C:3]1([CH2:14][CH3:15])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH3:12])[C:4]1=[O:13])[CH3:2].[N+:16]([O-])([OH:18])=[O:17]>S(=O)(=O)(O)O>[CH2:14]([C:3]1([CH2:1][CH3:2])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:16]([O-:18])=[O:17])[CH:10]=2)[N:5]([CH3:12])[C:4]1=[O:13])[CH3:15]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 23092669HCID 23092669, compound

Product 1

HCID 23092667HCID 23092667, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

To a solution of 3,3-diethyl-1-methyl-1,3-dihydro-indol-2-one (J. Chem. Soc., 1971, 1375) (7.6 g) in concentrated sulfuric acid (12 ml) is added a mixture of nitric acid (65%, 2.7 ml) and concentrated sulfuric acid (4.4 ml) at 0° C. over a period of 30 min. The reaction mixture is stirred at this temperature for 30 min and then poured into ice water. The precipitate is collected by filtration and washed with water to give the respective compound (9.3 g).

Workup

  1. filtrationThe precipitate is collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-05e871f8687e40f1802563c432620d06
Source dataset
uspto-grants-2010_05
Patent number
US07714010B2

Reaction notes

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